Ser675
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Home > Phosphorylation Site Page: > Ser675  -  TBX2 (mouse)

Site Information
GPsRGALsPSGsAKE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1308916

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 4 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 4 ) , western blotting ( 4 )
Disease tissue studied:
breast cancer ( 4 ) , neuroblastoma ( 2 ) , fibrosarcoma of soft tissue ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
P38A (human) ( 4 )
Kinases, in vitro:
P38A (human) ( 4 )
Treatments:
SB203580 ( 4 ) , UVC ( 4 )

Downstream Regulation
Effects of modification on TBX2:
activity, induced ( 4 ) , intracellular localization ( 4 ) , protein stabilization ( 4 )
Effects of modification on biological processes:
transcription, inhibited ( 4 )

References 

1

Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704
24719451   Curated Info

2

Wang Y, et al. (2011) Spatial phosphoprotein profiling reveals a compartmentalized extracellular signal-regulated kinase switch governing neurite growth and retraction. J Biol Chem 286, 18190-201
21454597   Curated Info

3

Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89
21183079   Curated Info

4

Abrahams A, et al. (2008) UV-mediated Regulation of the Anti-senescence Factor Tbx2. J Biol Chem 283, 2223-2230
18025091   Curated Info