Ser424
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Home > Phosphorylation Site Page: > Ser424  -  AML1 iso8 (human)

Site Information
SMVGGERsPPRILPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1308915

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
CDK1 (human) ( 1 , 2 ) , CDK6 (human) ( 2 )
Treatments:
LY294002 ( 1 ) , PP2 ( 1 ) , seliciclib ( 1 , 2 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on AML1 iso8:
activity, induced ( 2 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
cell growth, altered ( 1 ) , cell growth, induced ( 2 ) , transcription, induced ( 2 )
Inhibit interaction with:
HDAC1 (human) ( 1 ) , HDAC3 (human) ( 1 )

References 

1

Guo H, Friedman AD (2011) Phosphorylation of RUNX1 by cyclin-dependent kinase reduces direct interaction with HDAC1 and HDAC3. J Biol Chem 286, 208-15
21059642   Curated Info

2

Zhang L, Fried FB, Guo H, Friedman AD (2008) Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation. Blood 111, 1193-200
18003885   Curated Info