Ser138
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Home > Phosphorylation Site Page: > Ser138  -  IGFBP3 (human)

Site Information
PPAPGNAsEsEEDRs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451462

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 1 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
P38A (human) ( 1 )
Putative in vivo kinases:
CK2A1 (human) ( 1 )
Kinases, in vitro:
CK2A1 (human) ( 2 )
Treatments:
BIRB-0796 ( 1 ) , high_glucose ( 1 ) , TBB ( 1 ) , TNF ( 1 )

Downstream Regulation
Effects of modification on biological processes:
apoptosis, induced ( 2 )

References 

1

Zhang Q, Soderland D, Steinle JJ (2014) TNFα Inhibits IGFBP-3 through Activation of p38α and Casein Kinase 2 in Human Retinal Endothelial Cells. PLoS One 9, e103578
25073020   Curated Info

2

Hollowood AD, et al. (2002) Evidence implicating a mid-region sequence of IGFBP-3 in its specific IGF-independent actions. J Cell Biochem 86, 583-9
12210764   Curated Info

3

Hoeck WG, Mukku VR (1994) Identification of the major sites of phosphorylation in IGF binding protein-3. J Cell Biochem 56, 262-73
7530253   Curated Info