Ser245
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Home > Phosphorylation Site Page: > Ser245  -  ATF-4 (human)

Site Information
TrGSPNRsLPsPGVL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451446

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , electrophoretic mobility shift ( 4 ) , immunoprecipitation ( 4 ) , mass spectrometry ( 2 ) , phospho-antibody ( 1 , 3 , 4 ) , western blotting ( 1 , 3 )
Disease tissue studied:
breast cancer ( 3 ) , lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:
breast ( 3 ) , Jurkat (T lymphocyte) ( 2 ) , lung ( 1 ) , MCF-10A (breast cell) ( 3 ) , MCF-7 (breast cell) ( 3 ) , MDA-MB-231 (breast cell) ( 3 ) , NCI-H157 (pulmonary) ( 1 ) , osteoblast-calvarium ( 4 )

Upstream Regulation
Putative in vivo kinases:
RSK2 (human) ( 4 )
Kinases, in vitro:
RSK2 (human) ( 4 )
Treatments:
phorbol_ester ( 4 )

Downstream Regulation
Effects of modification on ATF-4:
activity, induced ( 4 )
Effects of modification on biological processes:
carcinogenesis, induced ( 3 ) , cell growth, altered ( 4 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 3 ) , non-small cell lung cancer ( 1 )

References 

1

Fan CF, et al. (2014) Expression of a phosphorylated form of ATF4 in lung and non-small cell lung cancer tissues. Tumour Biol 35, 765-71
23975372   Curated Info

2

Mertins P, et al. (2013) Integrated proteomic analysis of post-translational modifications by serial enrichment. Nat Methods 10, 634-7
23749302   Curated Info

3

Fan CF, Mao XY, Wang EH (2012) Elevated p-CREB-2 (ser 245) expression is potentially associated with carcinogenesis and development of breast carcinoma. Mol Med Report 5, 357-62
22052162   Curated Info

4

Yang X, et al. (2004) ATF4 is a substrate of RSK2 and an essential regulator of osteoblast biology; implication for Coffin-Lowry Syndrome. Cell 117, 387-98
15109498   Curated Info

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