Ser522
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Home > Phosphorylation Site Page: > Ser522  -  CRMP-1 (human)

Site Information
PAPsAKssPsKHQPP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1295503

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 , 2 ) , microscopy-colocalization with upstream kinase ( 3 ) , mutation of modification site ( 3 )
Disease tissue studied:
Alzheimer's disease ( 2 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 2 ) , HeLa (cervical) ( 1 ) , neuron-'brain, cerebral cortex' [CRMP-1 (mouse)] ( 3 )

Upstream Regulation
Putative in vivo kinases:
CDK5 (mouse) ( 3 )
Kinases, in vitro:
CDK5 (human) ( 4 ) , DYRK2 (human) ( 4 )
Treatments:
BI2536 ( 1 )

Downstream Regulation
Effects of modification on biological processes:
cytoskeletal reorganization ( 3 )

References 

1

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

2

Xia Q, et al. (2008) Phosphoproteomic analysis of human brain by calcium phosphate precipitation and mass spectrometry. J Proteome Res 7, 2845-51
18510355   Curated Info

3

Yamashita N, et al. (2007) Regulation of spine development by semaphorin3A through cyclin-dependent kinase 5 phosphorylation of collapsin response mediator protein 1. J Neurosci 27, 12546-54
18003833   Curated Info

4

Cole AR, et al. (2006) Distinct priming kinases contribute to differential regulation of collapsin response mediator proteins by glycogen synthase kinase-3 in vivo. J Biol Chem 281, 16591-8
16611631   Curated Info