Ser373
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus®
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser373  -  CIITA (human)

Site Information
VQARLERsSSKSLER   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1295502

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:
293FT ( 1 ) , IMR-90 (fibroblast) ( 1 )

Upstream Regulation
Kinases, in vitro:
GSK3B (human) ( 1 )

Downstream Regulation
Effects of modification on CIITA:
activity, inhibited ( 1 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, inhibited ( 1 )
Induce interaction with:
SIN3B (human) ( 1 )

References 

1

Xu Y, Harton JA, Smith BD (2008) CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules. J Biol Chem 283, 1243-56
17991736   Curated Info