Ser36
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Home > Phosphorylation Site Page: > Ser36  -  AHR (human)

Site Information
EGIkSNPsKRHRDRL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451413

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
liver cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
PKCA (human) ( 2 )
Putative upstream phosphatases:
PPP2CA (human) ( 1 )
Treatments:
benzo(a)pyrene ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on AHR:
intracellular localization ( 2 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 ) , carcinogenesis, induced ( 1 ) , transcription, altered ( 2 )

References 

1

Chen L, et al. (2022) Protein phosphatase 2A regulates cytotoxicity and drug resistance by dephosphorylating xenobiotic metabolism enzymes AHR and MDR1. J Biol Chem, 101918
35405096   Curated Info

2

Ikuta T, Kobayashi Y, Kawajiri K (2004) Phosphorylation of nuclear localization signal inhibits the ligand-dependent nuclear import of aryl hydrocarbon receptor. Biochem Biophys Res Commun 317, 545-50
15063792   Curated Info