Ser772
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Home > Phosphorylation Site Page: > Ser772  -  Rb (rat)

Site Information
STRPPTLsPIPHIPR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 447978

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 5 ) , phospho-antibody ( 2 , 4 , 6 , 7 , 8 ) , western blotting ( 2 , 4 , 6 , 7 , 8 )
Disease tissue studied:
neuroblastoma ( 4 )
Relevant cell line - cell type - tissue:
'neuron, cortical'-brain ( 5 ) , astrocyte-'brain, cerebrum' ( 6 ) , B65 (neuron) ( 4 ) , glial ( 2 ) , hepatic stellate ( 7 ) , vascular smooth muscle cell ('muscle, smooth') ( 8 )

Upstream Regulation
Regulatory protein:
ATM (human) ( 4 )
Treatments:
5-HT ( 8 ) , BDNF ( 2 ) , CBX ( 6 ) , endothelin ( 6 ) , H2O2 ( 4 ) , KU-55933 ( 4 ) , PDGF ( 7 ) , RANTES ( 2 ) , rapamycin ( 7 ) , serum ( 8 ) , tolbutamide ( 6 ) , virus infection ( 2 )

Downstream Regulation
Effects of modification on Rb:
molecular association, regulation ( 5 )
Induce interaction with:
HDAC1 (human) ( 5 )

References 

1

Park JH, Arakawa-Takeuchi S, Jinno S, Okayama H (2011) Rho-associated Kinase Connects a Cell Cycle-controlling Anchorage Signal to the Mammalian Target of Rapamycin Pathway. J Biol Chem 286, 23132-41
21561859   Curated Info

2

Akay C, et al. (2011) Site-specific hyperphosphorylation of pRb in HIV-induced neurotoxicity. Mol Cell Neurosci 47, 154-65
21504794   Curated Info

3

Blancquaert S, et al. (2010) cAMP-dependent activation of mammalian target of rapamycin (mTOR) in thyroid cells. Implication in mitogenesis and activation of CDK4. Mol Endocrinol 24, 1453-68
20484410   Curated Info

4

Pizarro JG, et al. (2010) ATM is involved in cell-cycle control through the regulation of retinoblastoma protein phosphorylation. J Cell Biochem 110, 210-8
20213763   Curated Info

5

Qiu Z, Ghosh A (2008) A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron 60, 775-87
19081374   Curated Info

6

Tabernero A, Sánchez-Alvarez R, Medina JM (2006) Increased levels of cyclins D1 and D3 after inhibition of gap junctional communication in astrocytes. J Neurochem 96, 973-82
16412096   Curated Info

7

Gäbele E, et al. (2005) The role of p70S6K in hepatic stellate cell collagen gene expression and cell proliferation. J Biol Chem 280, 13374-82
15677443   Curated Info

8

Garnovskaya MN, et al. (2004) Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation. J Biol Chem 279, 24899-905
15069084   Curated Info