Ser803
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.8
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Ser803  -  Rb (rat)

Site Information
IYIsPLKsPYKISEG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448717

In vivo Characterization
Methods used to characterize site in vivo:
phospho-antibody ( 2 , 3 , 4 , 5 ) , western blotting ( 2 , 3 , 4 , 5 )
Disease tissue studied:
adrenal cancer ( 4 ) , pheochromocytoma ( 4 )
Relevant cell line - cell type - tissue:
astrocyte-'brain, cerebrum' ( 3 ) , glial ( 2 ) , PC-12 (chromaffin) ( 4 ) , vascular smooth muscle cell ('muscle, smooth') ( 5 )

Upstream Regulation
Regulatory protein:
ENC1 (rat) ( 4 )
Treatments:
5-HT ( 5 ) , BDNF ( 2 ) , CBX ( 3 ) , endothelin ( 3 ) , RANTES ( 2 ) , serum ( 5 ) , siRNA ( 4 ) , virus infection ( 2 )

References 

1

Park JH, Arakawa-Takeuchi S, Jinno S, Okayama H (2011) Rho-associated Kinase Connects a Cell Cycle-controlling Anchorage Signal to the Mammalian Target of Rapamycin Pathway. J Biol Chem 286, 23132-41
21561859   Curated Info

2

Akay C, et al. (2011) Site-specific hyperphosphorylation of pRb in HIV-induced neurotoxicity. Mol Cell Neurosci 47, 154-65
21504794   Curated Info

3

Tabernero A, Sánchez-Alvarez R, Medina JM (2006) Increased levels of cyclins D1 and D3 after inhibition of gap junctional communication in astrocytes. J Neurochem 96, 973-82
16412096   Curated Info

4

Kim TA, et al. (2005) The BTB domain of the nuclear matrix protein NRP/B is required for neurite outgrowth. J Cell Sci 118, 5537-48
16306221   Curated Info

5

Garnovskaya MN, et al. (2004) Mitogen-induced rapid phosphorylation of serine 795 of the retinoblastoma gene product in vascular smooth muscle cells involves ERK activation. J Biol Chem 279, 24899-905
15069084   Curated Info