Thr337
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Home > Phosphorylation Site Page: > Thr337  -  TXA2-R (human)

Site Information
LsLQPQLtQRSGLQ_   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451395

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , mass spectrometry ( 2 , 3 ) , mutation of modification site ( 4 , 5 ) , western blotting ( 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 4 , 5 ) , HeLa (cervical) ( 3 ) , mesangial-kidney ( 5 ) , T lymphocyte-blood ( 2 )

Upstream Regulation
Putative in vivo kinases:
PKCA (human) ( 4 , 5 )
Treatments:
anti-CD3 ( 2 ) , dinoprost ( 5 ) , GF109203X ( 4 , 5 ) , PGE2 ( 5 ) , U46619 ( 4 )

Downstream Regulation
Effects of modification on TXA2-R:
receptor desensitization, altered ( 5 ) , receptor desensitization, induced ( 4 )
Effects of modification on biological processes:
signaling pathway regulation ( 4 )

References 

1

Schweppe DK, Rigas JR, Gerber SA (2013) Quantitative phosphoproteomic profiling of human non-small cell lung cancer tumors. J Proteomics 91, 286-96
23911959   Curated Info

2

Ruperez P, Gago-Martinez A, Burlingame AL, Oses-Prieto JA (2012) Quantitative phosphoproteomic analysis reveals a role for serine and threonine kinases in the cytoskeletal reorganization in early T cell receptor activation in human primary T cells. Mol Cell Proteomics 11, 171-86
22499768   Curated Info

3

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

4

Kelley-Hickie LP, O'Keeffe MB, Reid HM, Kinsella BT (2007) Homologous desensitization of signalling by the alpha (alpha) isoform of the human thromboxane A2 receptor: a specific role for nitric oxide signalling. Biochim Biophys Acta 1773, 970-89
17466390   Curated Info

5

Kelley-Hickie LP, Kinsella BT (2004) EP1- and FP-mediated cross-desensitization of the alpha (alpha) and beta (beta) isoforms of the human thromboxane A2 receptor. Br J Pharmacol 142, 203-21
15100160   Curated Info