Thr381
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Home > Phosphorylation Site Page: > Thr381  -  calsequestrin 1 (rabbit)

Site Information
VLEGEINtEDDDDED   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451337

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 )
Relevant cell line - cell type - tissue:
'muscle, skeletal' ( 2 ) , HeLa (cervical) ( 2 ) , myoblast ( 2 )

Upstream Regulation
Kinases, in vitro:
CK2A1 (human) ( 1 ) , CK2A1 (rat) ( 3 )

Downstream Regulation
Effects of modification on calsequestrin 1:
molecular association, regulation ( 1 )
Induce interaction with:
ASPH (rabbit) ( 1 )

References 

1

Beard NA, et al. (2008) Phosphorylation of skeletal muscle calsequestrin enhances its Ca(2+) binding capacity and promotes its association with junctin. Cell Calcium 44, 363-373
19230141   Curated Info

2

Nori A, et al. (2000) Site-directed mutagenesis and deletion of three phosphorylation sites of calsequestrin of skeletal muscle sarcoplasmic reticulum. Effects on intracellular targeting. Exp Cell Res 260, 40-9
11010809   Curated Info

3

Cala SE, Jones LR (1991) Phosphorylation of cardiac and skeletal muscle calsequestrin isoforms by casein kinase II. Demonstration of a cluster of unique rapidly phosphorylated sites in cardiac calsequestrin. J Biol Chem 266, 391-8
1985907   Curated Info