Lys1130
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Home > Sumoylation Site Page: > Lys1130  -  IGF1R (human)

Site Information
MAYLNANkFVHRDLA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12723517

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , mutation of modification site ( 1 , 2 ) , western blotting ( 1 )
Disease tissue studied:
leukemia ( 1 ) , leiomyosarcoma ( 2 )
Relevant cell line - cell type - tissue:
HL60 (myeloid) ( 1 ) , SKUT-1 ( 2 )

Downstream Regulation
Effects of modification on IGF1R:
intracellular localization ( 2 )
Effects of modification on biological processes:
cell growth, induced ( 1 ) , transcription, induced ( 2 )
Induce interaction with:
DNA ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
acute myelogenous leukemia ( 1 )

References 

1

Zhang J, et al. (2015) SUMOylation of insulin-like growth factor 1 receptor, promotes proliferation in acute myeloid leukemia. Cancer Lett 357, 297-306
25448401   Curated Info

2

Sehat B, et al. (2010) SUMOylation Mediates the Nuclear Translocation and Signaling of the IGF-1 Receptor. Sci Signal 3, ra10
20145208   Curated Info

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