Lys14
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Home > Ubiquitylation Site Page: > Lys14  -  Akt1 (human)

Site Information
VkEGWLHkRGEYIkT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12723502

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 4 ) , mass spectrometry ( 1 , 3 ) , mutation of modification site ( 4 ) , western blotting ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
IGF-1 ( 4 ) , serum ( 4 )

Downstream Regulation
Effects of modification on Akt1:
enzymatic activity, induced ( 4 ) , intracellular localization ( 4 ) , phosphorylation ( 4 )

References 

1

Akimov V, et al. (2018) UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol 25, 631-640
29967540   Curated Info

2

Boeing S, et al. (2016) Multiomic Analysis of the UV-Induced DNA Damage Response. Cell Rep 15, 1597-1610
27184836   Curated Info

3

Udeshi ND, et al. (2013) Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Mol Cell Proteomics 12, 825-31
23266961   Curated Info

4

Yang WL, et al. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325, 1134-8
19713527   Curated Info