Tyr215
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Home > Phosphorylation Site Page: > Tyr215  -  cGAS (human)

Site Information
LLNTGSYyEHVKISA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1271626200

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
BLK (human) ( 1 )
Treatments:
etoposide ( 1 ) , vanadate ( 1 )

Downstream Regulation
Effects of modification on cGAS:
intracellular localization ( 1 )
Effects of modification on biological processes:
DNA repair, inhibited ( 1 )

References 

1

Liu H, et al. (2018) Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature 563, 131-136
30356214   Curated Info