Thr299
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Home > Phosphorylation Site Page: > Thr299  -  MASTL (human)

Site Information
QsRKRLAtSSAsSQS   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1269647500

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Disease tissue studied:
bone cancer ( 1 ) , colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 1 ) , SW480 (intestinal) ( 1 ) , U2OS (bone cell) ( 1 )

Upstream Regulation
Putative in vivo kinases:
Akt1 (human) ( 1 )
Treatments:
LY294002 ( 1 )

Downstream Regulation
Effects of modification on MASTL:
enzymatic activity, induced ( 1 ) , protein degradation ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell cycle regulation ( 1 )

References 

1

Reshi I, et al. (2020) AKT regulates mitotic progression of mammalian cells by phosphorylating MASTL leading to PP2A inactivation. Mol Cell Biol
32123010   Curated Info

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