Tyr328
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Home > Phosphorylation Site Page: > Tyr328  -  HDAC3 (human)

Site Information
EELPySEyFEyFAPD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1267669101

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 , 2 )
Disease tissue studied:
breast cancer ( 1 ) , colorectal cancer ( 2 ) , colorectal carcinoma ( 2 )
Relevant cell line - cell type - tissue:
HCT116 (intestinal) ( 2 ) , HEK293T (epithelial) ( 1 , 2 ) , MCF-7 (breast cell) ( 1 ) , MDA-MB-231 (breast cell) ( 1 )

Upstream Regulation
Regulatory protein:
EGFR (human) ( 1 )
Putative in vivo kinases:
Src (human) ( 1 , 2 )
Kinases, in vitro:
Src (human) ( 1 )
Treatments:
EGF ( 1 ) , PP2 ( 1 ) , siRNA ( 1 )

Downstream Regulation
Effects of modification on HDAC3:
activity, induced ( 2 ) , enzymatic activity, induced ( 1 ) , intracellular localization ( 1 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 2 )

References 

1

Kwak SM, et al. (2019) EGFR-c-Src-Mediated HDAC3 Phosphorylation Exacerbates Invasion of Breast Cancer Cells. Cells 8
31430896   Curated Info

2

Seo J, et al. (2018) Tyrosine phosphorylation of HDAC3 by Src kinase mediates proliferation of HER2-positive breast cancer cells. J Cell Physiol 234
30317579   Curated Info

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