Ser369
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Home > Phosphorylation Site Page: > Ser369  -  CAPN2 (human)

Site Information
DGNWRRGstAGGCRN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451303

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
'muscle, smooth'-pulmonary artery ( 1 ) , HEK293T (epithelial) ( 1 ) , NR6WT (fibroblast) ( 2 ) , PASM ( 1 )

Upstream Regulation
Putative in vivo kinases:
PKACA (human) ( 2 )
Treatments:
5-HT ( 1 ) , 8-Rp-cAMP ( 2 ) , cAMP_analog ( 2 ) , endothelin ( 1 ) , fostriecin ( 1 ) , H-89 ( 2 ) , H2O2 ( 1 ) , IL-6 ( 1 ) , PD98059 ( 1 ) , PDGF ( 1 )

Downstream Regulation
Effects of modification on CAPN2:
activity, inhibited ( 2 )
Effects of modification on biological processes:
cell motility, altered ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
PAH ( 1 )

References 

1

Kovacs L, et al. (2016) Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension. Am J Respir Cell Mol Biol 54, 384-93
26248159   Curated Info

2

Shiraha H, et al. (2002) Activation of m-calpain (calpain II) by epidermal growth factor is limited by protein kinase A phosphorylation of m-calpain. Mol Cell Biol 22, 2716-27
11909964   Curated Info