Tyr1077
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Home > Phosphorylation Site Page: > Tyr1077  -  LEPR (mouse)

Site Information
HREKSVCyLGVTSVN   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451292

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 2 , 3 , 4 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
adrenal cancer ( 4 ) , pheochromocytoma ( 4 ) , liver cancer ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Treatments:
high-fat diet ( 1 ) , IL-6 ( 1 )

Downstream Regulation
Effects of modification on LEPR:
activity, induced ( 3 ) , molecular association, regulation ( 4 ) , phosphorylation ( 2 )
Effects of modification on biological processes:
transcription, altered ( 2 )
Induce interaction with:
SOCS3 (mouse) ( 4 )

References 

1

Gavito AL, et al. (2016) Chronic IL-6 Administration Desensitizes IL-6 Response in Liver, Causes Hyperleptinemia and Aggravates Steatosis in Diet-Induced-Obese Mice. PLoS One 11, e0157956
27333268   Curated Info

2

Knobelspies H, et al. (2010) Mechanism of attenuation of leptin signaling under chronic ligand stimulation. BMC Biochem 11, 2
20059770   Curated Info

3

Hekerman P, et al. (2005) Pleiotropy of leptin receptor signalling is defined by distinct roles of the intracellular tyrosines. FEBS J 272, 109-19
15634336   Curated Info

4

Eyckerman S, et al. (2000) Identification of the Y985 and Y1077 motifs as SOCS3 recruitment sites in the murine leptin receptor. FEBS Lett 486, 33-7
11108838   Curated Info

5

Banks AS, Davis SM, Bates SH, Myers MG (2000) Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 275, 14563-72
10799542   Curated Info