Thr117
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Home > Phosphorylation Site Page: > Thr117  -  MST2 (human)

Site Information
IIRLRNktLIEDEIA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12615900

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , immunoprecipitation ( 2 , 3 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
breast cancer ( 2 ) , colorectal cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
PTEN (human) ( 2 )
Putative in vivo kinases:
Akt1 (human) ( 2 , 3 )
Kinases, in vitro:
Akt1 (human) ( 2 , 3 )
Treatments:
Akt-I-1 ( 2 ) , IGF-1 ( 2 , 3 ) , LY294002 ( 2 ) , serum ( 2 ) , serum_starvation ( 3 )

Downstream Regulation
Effects of modification on MST2:
enzymatic activity, inhibited ( 2 , 3 ) , intracellular localization ( 3 ) , molecular association, regulation ( 2 ) , phosphorylation ( 3 )
Effects of modification on biological processes:
apoptosis, altered ( 2 ) , carcinogenesis, induced ( 3 ) , cell growth, altered ( 3 ) , signaling pathway regulation ( 2 )
Induce interaction with:
RAF1 (human) ( 2 )
Inhibit interaction with:
MST2 (human) ( 2 ) , RASSF1 (human) ( 2 )

Disease / Diagnostics Relevance
Relevant diseases:
breast cancer ( 3 )

References 

1

Tucker M (2010) CST Curation Set: 9527; Year: 2010; Biosample/Treatment: tissue, colon/untreated; Disease: -; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Romano D, et al. (2010) Proapoptotic kinase MST2 coordinates signaling crosstalk between RASSF1A, Raf-1, and Akt. Cancer Res 70, 1195-203
20086174   Curated Info

3

Kim D, et al. (2010) Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway. PLoS One 5, e9616
20231902   Curated Info