Thr254
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Home > Phosphorylation Site Page: > Thr254  -  CD40 (human)

Site Information
TAAPVQEtLHGCQPV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451275

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 1 , 2 ) , mutation of modification site ( 1 , 2 )
Relevant cell line - cell type - tissue:
B lymphocyte-spleen ( 1 ) , CESS (lymphoblastoid) ( 2 ) , CH12.LX (B lymphocyte) ( 1 ) , M12 (B lymphocyte) ( 2 ) , SF9 ( 1 )

Upstream Regulation
Treatments:
IL-6 ( 2 ) , phorbol_ester ( 1 , 2 )

Downstream Regulation
Effects of modification on CD40:
activity, induced ( 2 ) , molecular association, regulation ( 1 )
Induce interaction with:
TRAF2 (mouse) ( 1 )

References 

1

Haxhinasto SA, Hostager BS, Bishop GA (2002) Cutting edge: molecular mechanisms of synergy between CD40 and the B cell antigen receptor: role for TNF receptor-associated factor 2 in receptor interaction. J Immunol 169, 1145-9
12133933   Curated Info

2

Clark EA, Shu G (1990) Association between IL-6 and CD40 signaling. IL-6 induces phosphorylation of CD40 receptors. J Immunol 145, 1400-6
1696597   Curated Info