Thr356
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Home > Phosphorylation Site Page: > Thr356  -  SSTR2 (rat)

Site Information
RLNEttEtQRtLLNG   SwissProt
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12577701

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 1 ) , mutation of modification site ( 3 ) , phospho-antibody ( 1 , 2 , 3 ) , western blotting ( 1 , 2 , 3 )
Disease tissue studied:
pancreatic cancer ( 3 ) , pancreatic carcinoma ( 3 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 , 2 , 3 ) , GH3 (epithelial) ( 3 ) , INS-1 (pancreatic) ( 3 ) , pancreas ( 3 ) , pituitary gland ( 3 )

Upstream Regulation
Putative in vivo kinases:
GRK2 (human) ( 3 ) , GRK3 (human) ( 3 )
Putative upstream phosphatases:
PPP1CB (human) ( 1 )
Treatments:
BIM23627 ( 3 ) , calyculin_A ( 1 ) , L779,976 ( 3 ) , octreotide ( 2 , 3 ) , okadaic_acid ( 1 ) , pasireotide ( 2 , 3 ) , phorbol_ester ( 3 ) , siRNA ( 3 ) , SST14 ( 1 , 2 , 3 )

Downstream Regulation
Effects of modification on SSTR2:
activity, induced ( 1 ) , intracellular localization ( 1 ) , receptor internalization, altered ( 3 )
Effects of modification on biological processes:
signaling pathway regulation ( 1 )

References 

1

Pöll F, Doll C, Schulz S (2011) Rapid Dephosphorylation of G Protein-coupled Receptors by Protein Phosphatase 1{beta} Is Required for Termination of {beta}-Arrestin-dependent Signaling. J Biol Chem 286, 32931-6
21795688   Curated Info

2

Nagel F, et al. (2011) Structural Determinants of Agonist-Selective Signaling at the sst2A Somatostatin Receptor. Mol Endocrinol 25, 859-66
21330405   Curated Info

3

Pöll F, et al. (2010) Pasireotide and octreotide stimulate distinct patterns of sst2A somatostatin receptor phosphorylation. Mol Endocrinol 24, 436-46
20051480   Curated Info