Thr21

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Home > Phosphorylation Site Page: > Thr21 - BMAL1 (human)

Site Information
DFMsPGPtDLLSSSL SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 12575204

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , MEF (fibroblast) ( 1 )

Upstream Regulation
Putative in vivo kinases:	GSK3B (human) ( 1 )
Kinases, in vitro:	GSK3B (human) ( 1 )

Downstream Regulation
Effects of modification on BMAL1:	protein degradation ( 1 )
Effects of modification on biological processes:	transcription, altered ( 1 )

References
1	Sahar S, et al. (2010) Regulation of BMAL1 protein stability and circadian function by GSK3beta-mediated phosphorylation. PLoS One 5, e8561 20049328 Curated Info

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