Ser697

Site Information
SSGTRRPsLDSTENQ SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 451267

In vivo Characterization
Methods used to characterize site in vivo:	immunoassay ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 4 )
Relevant cell line - cell type - tissue:	'neuron, cochlear' ( 2 ) , 'neuron, unipolar' ( 3 ) , brain ( 1 ) , colon ( 3 ) , spinal cord ( 4 )

Downstream Regulation
Effects of modification on Ret:	activity, induced ( 3 ) , phosphorylation ( 3 )
Effects of modification on biological processes:	cell motility, altered ( 3 ) , cytoskeletal reorganization ( 3 )

References
1	Trinidad JC, et al. (2012) Global identification and characterization of both O-GlcNAcylation and phosphorylation at the murine synapse. Mol Cell Proteomics 11, 215-29 22645316 Curated Info
2	Ohgami N, et al. (2012) Partial impairment of c-Ret at tyrosine 1062 accelerates age-related hearing loss in mice. Neurobiol Aging 33, 626.e25-34 21612845 Curated Info
3	Asai N, et al. (2006) Targeted mutation of serine 697 in the Ret tyrosine kinase causes migration defect of enteric neural crest cells. Development 133, 4507-16 17050626 Curated Info
4	Zhang J, Huang EJ (2006) Dynamic expression of neurotrophic factor receptors in postnatal spinal motoneurons and in mouse model of ALS. J Neurobiol 66, 882-95 16680759 Curated Info