Ser5

Site Information
___MKAFsPVRSVRK SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 451265

In vivo Characterization
Methods used to characterize site in vivo:	mass spectrometry ( 1 , 2 , 3 ) , mutation of modification site ( 4 ) , western blotting ( 4 )
Relevant cell line - cell type - tissue:	C2C12 (myoblast) ( 4 ) , RAW 264.7 (macrophage) ( 1 ) , spleen ( 3 ) , stromal ( 2 )

Downstream Regulation
Effects of modification on ID2:	intracellular localization ( 4 )
Effects of modification on biological processes:	apoptosis, altered ( 4 ) , cell cycle regulation ( 4 ) , cell growth, altered ( 4 )

References
1	Pinto SM, et al. (2015) Quantitative phosphoproteomic analysis of IL-33-mediated signaling. Proteomics 15, 532-44 25367039 Curated Info
2	Mertins P, et al. (2014) Ischemia in tumors induces early and sustained phosphorylation changes in stress kinase pathways but does not affect global protein levels. Mol Cell Proteomics 13, 1690-704 24719451 Curated Info
3	Huttlin EL, et al. (2010) A tissue-specific atlas of mouse protein phosphorylation and expression. Cell 143, 1174-89 21183079 Curated Info
4	Butler DC, Haramizu S, Williamson DL, Always SE (2009) Phospho-ablated Id2 is growth suppressive and pro-apoptotic in proliferating myoblasts. PLoS One 4, e6302 19609365 Curated Info