Ser1043

Site Information
CRPEALNsGVEYYWD SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 1255792404

In vivo Characterization
Methods used to characterize site in vivo:	mutation of modification site ( 1 , 2 ) , phospho-antibody ( 2 ) , western blotting ( 2 )
Disease tissue studied:	colorectal cancer ( 1 ) , colorectal carcinoma ( 1 ) , neuroblastoma ( 2 )
Relevant cell line - cell type - tissue:	HEK293T (epithelial) ( 1 ) , HeLa (cervical) ( 2 ) , HIEC-6 ( 1 ) , HT-29 (intestinal) ( 1 ) , SH-SY5Y (neural crest) ( 2 )

Downstream Regulation
Effects of modification on AMBRA1:	molecular association, regulation ( 1 , 2 ) , protein conformation ( 2 ) , protein stabilization ( 1 , 2 ) , ubiquitination ( 1 )
Effects of modification on biological processes:	autophagy, induced ( 2 )
Induce interaction with:	GABARAP (human) ( 2 ) , LC3B (human) ( 2 )
Inhibit interaction with:	CUL4A ( 1 )

References
1	Xu W, et al. (2024) AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner. Cell Death Differ 38424148 Curated Info
2	Di Rita A, et al. (2018) HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα. Nat Commun 9, 3755 30217973 Curated Info