Ser1043
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Home > Phosphorylation Site Page: > Ser1043  -  AMBRA1 (human)

Site Information
CRPEALNsGVEYYWD   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 1255792404

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
neuroblastoma ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
HUWE1 (human) ( 1 )
Putative in vivo kinases:
IKKA (human) ( 1 )
Kinases, in vitro:
IKKA (human) ( 1 )
Treatments:
Bay_11-7082 ( 1 ) , hypoxia/reoxygenation ( 1 )

Downstream Regulation
Effects of modification on AMBRA1:
molecular association, regulation ( 1 ) , protein conformation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
autophagy, induced ( 1 )
Induce interaction with:
GABARAP (human) ( 1 ) , LC3B (human) ( 1 )

References 

1

Di Rita A, et al. (2018) HUWE1 E3 ligase promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKK╬▒. Nat Commun 9, 3755
30217973   Curated Info