Thr117
Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage PhosphoSitePlus® v6.5.9.3
Powered by Cell Signaling Technology
Home > Phosphorylation Site Page: > Thr117  -  OBFC2B (human)

Site Information
EPNPEYstQQAPNKA   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12526701

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 1 , 4 ) , western blotting ( 1 , 2 , 4 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , fibroblast-foreskin ( 4 ) , HEK293T (epithelial) ( 2 ) , HeLa (cervical) ( 1 ) , Sf21 ( 3 )

Upstream Regulation
Regulatory protein:
OBFC2B (human) ( 4 )
Kinases, in vitro:
ATM (human) ( 4 )
Treatments:
ionizing_radiation ( 4 )

Downstream Regulation
Effects of modification on OBFC2B:
protein stabilization ( 2 , 3 )
Induce interaction with:
DNA ( 3 )
Inhibit interaction with:
FBXO15 (human) ( 2 )

References 

1

Ashton NW, et al. (2017) hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases. DNA Repair (Amst) 54, 30-39
28448822   Curated Info

2

Chen ZW, et al. (2015) FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response. Nucleic Acids Res 42, 11560-9
25249620   Curated Info

3

Yang SH, et al. (2013) The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. EMBO J 32, 126-39
23178594   Curated Info

4

Richard DJ, et al. (2008) Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature 453, 677-81
18449195   Curated Info