Thr117

Site Information
EPNPEYstQQAPNKA SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 12526701

In vivo Characterization
Methods used to characterize site in vivo:	immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 1 , 4 ) , western blotting ( 1 , 2 , 4 )
Relevant cell line - cell type - tissue:	293 (epithelial) ( 1 ) , fibroblast-foreskin ( 4 ) , HEK293T (epithelial) ( 2 ) , HeLa (cervical) ( 1 ) , Sf21 ( 3 )

Downstream Regulation
Effects of modification on OBFC2B:	protein stabilization ( 2 , 3 )
Induce interaction with:	DNA ( 3 )
Inhibit interaction with:	FBXO15 (human) ( 2 )

References
1	Ashton NW, et al. (2017) hSSB1 phosphorylation is dynamically regulated by DNA-PK and PPP-family protein phosphatases. DNA Repair (Amst) 54, 30-39 28448822 Curated Info
2	Chen ZW, et al. (2015) FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response. Nucleic Acids Res 42, 11560-9 25249620 Curated Info
3	Yang SH, et al. (2013) The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. EMBO J 32, 126-39 23178594 Curated Info
4	Richard DJ, et al. (2008) Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature 453, 677-81 18449195 Curated Info