Tyr283
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Home > Phosphorylation Site Page: > Tyr283  -  SHC3 iso2 (human)

Site Information
RQGSSDIySTPEGKL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451257

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 ) , mass spectrometry ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 2 ) , phosphopeptide mapping ( 2 )
Disease tissue studied:
adrenal cancer ( 2 ) , pheochromocytoma ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
EGFR (human) ( 2 ) , Src (human) ( 2 ) , TrkA (human) ( 2 ) , TrkB (human) ( 2 )
Treatments:
EGF ( 2 ) , NGF ( 2 )

Downstream Regulation
Effects of modification on SHC3 iso2:
molecular association, regulation ( 2 )
Induce interaction with:
CRK (human) ( 2 ) , RAPGEF1 (human) ( 2 )

References 

1

Moritz A (2008) CST Curation Set: 5774; Year: 2008; Biosample/Treatment: cell line, NCI-H3255/Iressa; Disease: non-small cell lung cancer; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

2

Nakamura T, et al. (2002) Discrimination between phosphotyrosine-mediated signaling properties of conventional and neuronal Shc adapter molecules. Oncogene 21, 22-31
11791173   Curated Info