Thr456
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Home > Phosphorylation Site Page: > Thr456  -  CAD (hamster)

Site Information
KVYFLPItPHYVTQV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451248

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 1 , 3 ) , phospho-antibody ( 1 ) , phosphopeptide mapping ( 3 )
Relevant cell line - cell type - tissue:
BHK165-23 (fibroblast) ( 1 ) , GN4 (epithelial) ( 3 )

Upstream Regulation
Putative in vivo kinases:
ERK1 (rat) ( 3 )
Kinases, in vitro:
ERK1 (human) ( 2 ) , ERK2 (human) ( 2 , 3 )
Treatments:
bisindolylmaleimide ( 1 ) , EGF ( 1 , 3 ) , H-89 ( 1 ) , PD98059 ( 1 , 3 ) , PDGF ( 3 ) , phorbol_ester ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on CAD:
enzymatic activity, induced ( 3 )

References 

1

Sigoillot FD, et al. (2007) Protein kinase C modulates the up-regulation of the pyrimidine biosynthetic complex, CAD, by MAP kinase. Front Biosci 12, 3892-8
17485345   Curated Info

2

Sigoillot FD, Evans DR, Guy HI (2002) Growth-dependent regulation of mammalian pyrimidine biosynthesis by the protein kinase A and MAPK signaling cascades. J Biol Chem 277, 15745-51
11872754   Curated Info

3

Graves LM, et al. (2000) Regulation of carbamoyl phosphate synthetase by MAP kinase. Nature 403, 328-32
10659854   Curated Info

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