Tyr337
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Home > Phosphorylation Site Page: > Tyr337  -  ROMK (human)

Site Information
SKTKEGKyRVDFHNF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451246

In vivo Characterization
Methods used to characterize site in vivo:
microscopy-colocalization with upstream kinase ( 2 ) , mutation of modification site ( 1 , 2 , 4 ) , western blotting ( 2 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Regulatory protein:
Src (human) ( 2 )
Putative in vivo kinases:
Src (human) ( 1 , 4 )
Kinases, in vitro:
Src (human) ( 3 )
Treatments:
herbimycin_A ( 2 ) , PAO ( 4 )

Downstream Regulation
Effects of modification on ROMK:
activity, inhibited ( 1 ) , intracellular localization ( 2 , 4 )

References 

1

Yue P, et al. (2009) Src family protein tyrosine kinase (PTK) modulates the effect of SGK1 and WNK4 on ROMK channels. Proc Natl Acad Sci U S A 106, 15061-6
19706464   Curated Info

2

Sterling H, Lin DH, Wei Y, Wang WH (2003) Tetanus toxin abolishes exocytosis of ROMK1 induced by inhibition of protein tyrosine kinase. Am J Physiol Renal Physiol 284, F510-7
12556363   Curated Info

3

Lin DH, et al. (2002) K depletion increases protein tyrosine kinase-mediated phosphorylation of ROMK. Am J Physiol Renal Physiol 283, F671-7
12217858   Curated Info

4

Sterling H, et al. (2002) Inhibition of protein-tyrosine phosphatase stimulates the dynamin-dependent endocytosis of ROMK1. J Biol Chem 277, 4317-23
11719519   Curated Info