Tyr4508
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Home > Phosphorylation Site Page: > Tyr4508  -  LRP1 (mouse)

Site Information
TNFTNPVyATLYMGG   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451245

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 , 2 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
macrophage-bone marrow ( 1 ) , monocyte-blood ( 1 ) , PEA-13 (fibroblast) ( 2 ) , RAW 264.7 (macrophage) ( 1 )

Upstream Regulation
Regulatory protein:
TLR2 (human) ( 1 ) , TLR3 (mouse) ( 1 ) , TLR4 (human) ( 1 ) , TLR9 (human) ( 1 )
Treatments:
LPS ( 1 ) , tPA ( 2 )

Downstream Regulation
Effects of modification on LRP1:
activity, induced ( 1 ) , molecular association, regulation ( 1 ) , receptor internalization, induced ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 2 ) , signaling pathway regulation ( 1 )
Induce interaction with:
CSK (human) ( 1 ) , RAB8A (human) ( 1 )

References 

1

Luo L, et al. (2018) TLR Crosstalk Activates LRP1 to Recruit Rab8a and PI3Kγ for Suppression of Inflammatory Responses. Cell Rep 24, 3033-3044
30208326   Curated Info

2

Lin L, et al. (2010) tPA activates LDL receptor-related protein 1-mediated mitogenic signaling involving the p90RSK and GSK3beta pathway. Am J Pathol 177, 1687-96
20724593   Curated Info