Lys81
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Home > Ubiquitylation Site Page: > Lys81  -  POLB (human)

Site Information
DEFLATGkLrKLEKI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12486800

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 1 ) , mass spectrometry (in vitro) ( 2 , 3 ) , mutation of modification site ( 3 ) , western blotting ( 3 )
Relevant cell line - cell type - tissue:
HeLa (cervical) ( 3 ) , HEp-2 (squamous) ( 1 ) , Jurkat (T lymphocyte) ( 1 )

Upstream Regulation
Regulatory protein:
ARF GAP1 (human) ( 3 )

Downstream Regulation
Effects of modification on POLB:
protein degradation ( 3 )
Effects of modification on biological processes:
DNA repair, inhibited ( 3 )

References 

1

Akimov V, et al. (2018) UbiSite approach for comprehensive mapping of lysine and N-terminal ubiquitination sites. Nat Struct Mol Biol 25, 631-640
29967540   Curated Info

2

Ueda R, et al. (2009) Identification of cell-active lysine specific demethylase 1-selective inhibitors. J Am Chem Soc 131, 17536-7
19950987   Curated Info

3

Parsons JL, et al. (2009) Ubiquitin ligase ARF-BP1/Mule modulates base excision repair. EMBO J 28, 3207-15
19713937   Curated Info

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