Ser178
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Home > Phosphorylation Site Page: > Ser178  -  GATA1 (mouse)

Site Information
PFFSPTGsPLSSAAY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451236

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 2 , 3 ) , mutation of modification site ( 2 , 3 ) , phosphoamino acid analysis ( 3 ) , phosphopeptide mapping ( 2 , 3 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Kinases, in vitro:
ERK1 (human) ( 2 )
Treatments:
DMSO ( 3 ) , DNA_binding ( 1 ) , U0126 ( 1 )

Downstream Regulation
Effects of modification on GATA1:
molecular association, regulation ( 2 )
Induce interaction with:
LMO2 (human) ( 2 )

References 

1

Hernandez-Hernandez A, et al. (2006) Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1. EMBO J 25, 3264-74
16858405   Curated Info

2

Towatari M, et al. (2004) Involvement of mitogen-activated protein kinase in the cytokine-regulated phosphorylation of transcription factor GATA-1. Hematol J 5, 262-72
15167914   Curated Info

3

Crossley M, Orkin SH (1994) Phosphorylation of the erythroid transcription factor GATA-1. J Biol Chem 269, 16589-96
8206977   Curated Info