Ser310
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Home > Phosphorylation Site Page: > Ser310  -  GATA1 (mouse)

Site Information
QTRNRkAsGkGKKkR   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451231

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 5 ) , mutation of modification site ( 3 , 4 , 5 ) , phospho-antibody ( 1 , 4 ) , phosphoamino acid analysis ( 5 ) , phosphopeptide mapping ( 5 ) , western blotting ( 1 , 4 )
Disease tissue studied:
leukemia ( 4 ) , acute erythroid leukemias, including erythroleukemia (M6a) and very rare pure erythroid leukemia (M6b) ( 4 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 5 ) , erythroblast-spleen ( 1 ) , ES (stem) [GATA1 (mouse)] ( 4 ) , HCD 57 (erythroid) ( 4 ) , liver ( 3 ) , MEL (erythroid) ( 4 , 5 )

Upstream Regulation
Putative in vivo kinases:
Akt1 (mouse) ( 4 )
Kinases, in vitro:
Akt1 (human) ( 4 )
Treatments:
DMSO ( 5 ) , Epo ( 1 , 4 ) , HMBA ( 4 ) , LY294002 ( 4 ) , PD98059 ( 4 ) , SB203580 ( 4 ) , wortmannin ( 4 )

Downstream Regulation
Effects of modification on biological processes:
cell differentiation, altered ( 4 ) , transcription, induced ( 4 )

References 

1

Lin KR, Li CL, Yen JJ, Yang-Yen HF (2013) Constitutive Phosphorylation of GATA-1 at Serine(26) Attenuates the Colony-Forming Activity of Erythrocyte-Committed Progenitors. PLoS One 8, e64269
23717580   Curated Info

2

Hernandez-Hernandez A, et al. (2006) Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1. EMBO J 25, 3264-74
16858405   Curated Info

3

Rooke HM, Orkin SH (2006) Phosphorylation of Gata1 at serine residues 72, 142, and 310 is not essential for hematopoiesis in vivo. Blood 107, 3527-30
16391009   Curated Info

4

Zhao W, et al. (2006) Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway. Blood 107, 907-15
16204311   Curated Info

5

Crossley M, Orkin SH (1994) Phosphorylation of the erythroid transcription factor GATA-1. J Biol Chem 269, 16589-96
8206977   Curated Info