Thr205
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Home > Phosphorylation Site Page: > Thr205  -  Chk2 (human)

Site Information
VFVFFDLtVDDQsVY   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12473001

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mass spectrometry ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
bone cancer ( 1 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PLK1 (human) ( 1 )
Treatments:
BI2536 ( 1 )

Downstream Regulation
Effects of modification on Chk2:
enzymatic activity, inhibited ( 1 )
Effects of modification on biological processes:
cell cycle regulation ( 1 )

References 

1

van Vugt MA, et al. (2010) A Mitotic Phosphorylation Feedback Network Connects Cdk1, Plk1, 53BP1, and Chk2 to Inactivate the G(2)/M DNA Damage Checkpoint. PLoS Biol 8, e1000287
20126263   Curated Info