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Site Information |
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NFDFVtEtPLEGDFA SwissProt Entrez-Gene |
Blast this site against: NCBI SwissProt PDB |
Site Group ID: 451222 |
In vivo Characterization | |
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Methods used to characterize site in vivo: | |
Disease tissue studied: | |
Relevant cell line - cell type - tissue: |
Upstream Regulation | |
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Kinases, in vitro: | |
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Downstream Regulation | |
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Effects of modification on p21Cip1: | |
Effects of modification on biological processes: | |
Inhibit interaction with: |
References | |
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Colleoni B, et al. (2017) JNKs function as CDK4-activating kinases by phosphorylating CDK4 and p21. Oncogene 36, 4349-4361
28368408 Curated Info |
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Rizzardi LF, et al. (2015) CDK1-dependent Inhibition of the E3 Ubiquitin Ligase CRL4CDT2 Ensures Robust Transition from S Phase to Mitosis. J Biol Chem 290, 556-67
25411249 Curated Info |
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Foertsch F, et al. (2013) S100A11 is involved in the regulation of the stability of cell cycle regulator p21(CIP) (1/) (WAF) (1) in human keratinocyte HaCaT cells. FEBS J 280, 3840-53
23745637 Curated Info |
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Bisteau X, et al. (2013) CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point. PLoS Genet 9, e1003546
23737759 Curated Info |
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Densham RM, et al. (2009) MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability. Mol Cell Biol 29, 6380-90
19822666 Curated Info |
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Hwang CY, Lee C, Kwon KS (2009) Extracellular signal-regulated kinase 2-dependent phosphorylation induces cytoplasmic localization and degradation of p21Cip1. Mol Cell Biol 29, 3379-89
19364816 Curated Info |
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Kim GY, et al. (2002) The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation. J Biol Chem 277, 29792-802
12058028 Curated Info |
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Rössig L, et al. (2002) Glycogen synthase kinase-3 couples AKT-dependent signaling to the regulation of p21Cip1 degradation. J Biol Chem 277, 9684-9
11779850 Curated Info |