Ser307
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Home > Phosphorylation Site Page: > Ser307  -  MITF iso8 (mouse)

Site Information
IPSTGLCsPDLVNRI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451221

In vivo Characterization
Methods used to characterize site in vivo:
electrophoretic mobility shift ( 2 ) , immunoprecipitation ( 1 ) , mutation of modification site ( 1 , 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
COS (fibroblast) ( 2 ) , COS7 (fibroblast) ( 1 ) , RAW 264 (macrophage) ( 2 ) , RAW 264.7 (macrophage) ( 1 )

Upstream Regulation
Regulatory protein:
MKK6 (human) ( 1 )
Putative in vivo kinases:
P38A (mouse) ( 1 , 2 )
Kinases, in vitro:
P38A (mouse) ( 2 )
Treatments:
RANKL ( 2 ) , SB203580 ( 2 )

Downstream Regulation
Effects of modification on MITF iso8:
activity, induced ( 2 ) , molecular association, regulation ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )
Induce interaction with:
SMARCA4 (human) ( 1 ) , hnRNP P2 (human) ( 1 )

References 

1

Bronisz A, et al. (2014) The multifunctional protein fused in sarcoma (FUS) is a coactivator of microphthalmia-associated transcription factor (MITF). J Biol Chem 289, 326-34
24257758   Curated Info

2

Mansky KC, Sankar U, Han J, Ostrowski MC (2002) Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling. J Biol Chem 277, 11077-83
11792706   Curated Info

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