Thr623
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Home > Phosphorylation Site Page: > Thr623  -  ENaC-gamma (rat)

Site Information
PGSTVPGtPPPRYNT   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451220

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 4 ) , mutation of modification site ( 1 , 2 , 3 , 4 ) , phospho-antibody ( 1 , 4 ) , western blotting ( 1 , 3 )
Relevant cell line - cell type - tissue:
oocyte ( 1 , 3 ) , oocyte [CPEB (mouse)] ( 2 , 4 )

Upstream Regulation
Kinases, in vitro:
ERK1 (rat) ( 4 ) , ERK2 (rat) ( 4 )
Treatments:
colforsin ( 2 ) , IBMX ( 2 ) , progesterone ( 3 ) , seliciclib ( 2 )

Downstream Regulation
Effects of modification on ENaC-gamma:
activity, inhibited ( 4 ) , molecular association, regulation ( 2 , 4 )
Inhibit interaction with:
NEDD4L (mouse) ( 2 )

References 

1

Krueger B, Yang L, Korbmacher C, Rauh R (2018) The phosphorylation site T613 in the β-subunit of rat epithelial Nachannel (ENaC) modulates channel inhibition by Nedd4-2. Pflugers Arch
29397423   Curated Info

2

Yang LM, Rinke R, Korbmacher C (2006) Stimulation of the epithelial sodium channel (ENaC) by cAMP involves putative ERK phosphorylation sites in the C termini of the channel's beta- and gamma-subunit. J Biol Chem 281, 9859-68
16476738   Curated Info

3

Michlig S, et al. (2005) Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism. J Biol Chem 280, 38264-70
16172119   Curated Info

4

Shi H, et al. (2002) Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation. J Biol Chem 277, 13539-47
11805112   Curated Info

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