Tyr597
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Home > Phosphorylation Site Page: > Tyr597  -  DYN2 (rat)

Site Information
NTEQRNVykDLRQIE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451200

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 2 ) , mutation of modification site ( 1 , 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
pancreatic cancer ( 1 ) , pancreatic carcinoma ( 1 )
Relevant cell line - cell type - tissue:
BxPC-3 (pancreatic) ( 1 ) , Clone 9 (hepatic) ( 2 ) , fibroblast ( 2 ) , HeLa (cervical) ( 2 ) , RLMVEC (endothelial) ( 3 )

Upstream Regulation
Putative in vivo kinases:
Src (rat) ( 2 , 3 )
Treatments:
PP2 ( 2 ) , SU6656 ( 2 )

Downstream Regulation
Effects of modification on DYN2:
intracellular localization ( 3 ) , molecular association, regulation ( 3 )
Effects of modification on biological processes:
carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , cell motility, induced ( 1 ) , cytoskeletal reorganization ( 3 ) , exocytosis, induced ( 2 )
Induce interaction with:
caveolin-1 (rat) ( 3 )

References 

1

Eppinga RD, et al. (2012) Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma. Oncogene 31, 1228-41
21841817   Curated Info

2

Weller SG, et al. (2010) Src kinase regulates the integrity and function of the Golgi apparatus via activation of dynamin 2. Proc Natl Acad Sci U S A 107, 5863-8
20231454   Curated Info

3

Shajahan AN, et al. (2004) Role of Src-induced dynamin-2 phosphorylation in caveolae-mediated endocytosis in endothelial cells. J Biol Chem 279, 20392-400
15007081   Curated Info

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