Thr2022
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Home > Phosphorylation Site Page: > Thr2022  -  NACA (human)

Site Information
NIQENtQtPtVQEEs   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451197

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 8 ) , mass spectrometry ( 1 , 2 , 4 , 5 , 6 , 7 ) , mutation of modification site ( 8 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung adenocarcinoma ( 1 )
Relevant cell line - cell type - tissue:
293E (epithelial) ( 4 ) , COS (fibroblast) ( 8 ) , HeLa (cervical) ( 2 , 5 , 7 ) , Jurkat (T lymphocyte) ( 6 ) , PC9 (pulmonary) ( 1 )

Upstream Regulation
Putative in vivo kinases:
GSK3B (human) ( 8 )
Kinases, in vitro:
GSK3B (human) ( 8 )
Treatments:
indirubin ( 8 )

Downstream Regulation
Effects of modification on NACA:
intracellular localization ( 8 ) , protein stabilization ( 8 )
Effects of modification on biological processes:
transcription, altered ( 8 )

References 

1

Tsai CF, et al. (2015) Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics. Nat Commun 6, 6622
25814448   Curated Info

2

Sharma K, et al. (2014) Ultradeep human phosphoproteome reveals a distinct regulatory nature of Tyr and Ser/Thr-based signaling. Cell Rep 8, 1583-94
25159151   Curated Info

3

Beli P, et al. (2012) Proteomic Investigations Reveal a Role for RNA Processing Factor THRAP3 in the DNA Damage Response. Mol Cell 46, 212-25
22424773   Curated Info

4

Hsu PP, et al. (2011) The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-22
21659604   Curated Info

5

Kettenbach AN, et al. (2011) Quantitative phosphoproteomics identifies substrates and functional modules of aurora and polo-like kinase activities in mitotic cells. Sci Signal 4, rs5
21712546   Curated Info

6

Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46
19690332   Curated Info

7

Dephoure N, et al. (2008) A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A 105, 10762-7
18669648   Curated Info

8

Quélo I, Akhouayri O, Prud'homme J, St-Arnaud R (2004) GSK3 beta-dependent phosphorylation of the alpha NAC coactivator regulates its nuclear translocation and proteasome-mediated degradation. Biochemistry 43, 2906-14
15005626   Curated Info

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