Ser573
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Home > Phosphorylation Site Page: > Ser573  -  SCN2A (rat)

Site Information
LFsPrRNsRAsLFNF   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451193

In vivo Characterization
Methods used to characterize site in vivo:
[32P] bio-synthetic labeling ( 3 , 4 ) , mutation of modification site ( 1 , 2 , 3 ) , phosphopeptide mapping ( 4 )
Relevant cell line - cell type - tissue:

Upstream Regulation
Putative in vivo kinases:
PKACA (rat) ( 3 , 4 )
Kinases, in vitro:
PKACA (cow) ( 4 )
Phosphatases, in vitro:
PPP1CA (rat) ( 4 )
Treatments:
cAMP_analog ( 4 ) , colforsin ( 3 )

Downstream Regulation
Effects of modification on SCN2A:
activity, inhibited ( 1 , 2 , 3 )

References 

1

Cantrell AR, et al. (2002) Molecular mechanism of convergent regulation of brain Na(+) channels by protein kinase C and protein kinase A anchored to AKAP-15. Mol Cell Neurosci 21, 63-80
12359152   Curated Info

2

Cantrell AR, et al. (1997) Dopaminergic modulation of sodium current in hippocampal neurons via cAMP-dependent phosphorylation of specific sites in the sodium channel alpha subunit. J Neurosci 17, 7330-8
9295379   Curated Info

3

Smith RD, Goldin AL (1997) Phosphorylation at a single site in the rat brain sodium channel is necessary and sufficient for current reduction by protein kinase A. J Neurosci 17, 6086-93
9236220   Curated Info

4

Murphy BJ, Rossie S, De Jongh KS, Catterall WA (1993) Identification of the sites of selective phosphorylation and dephosphorylation of the rat brain Na+ channel alpha subunit by cAMP-dependent protein kinase and phosphoprotein phosphatases. J Biol Chem 268, 27355-62
8262976   Curated Info