Ser204
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Home > Phosphorylation Site Page: > Ser204  -  SMAD3 (mouse)

Site Information
NHSMDAGsPNLSPNP   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451178

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , western blotting ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 )

Downstream Regulation
Effects of modification on SMAD3:
enzymatic activity, induced ( 1 ) , molecular association, regulation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
apoptosis, induced ( 1 ) , signaling pathway regulation ( 1 ) , transcription, induced ( 1 )

Disease / Diagnostics Relevance
Relevant diseases:
obesity, hyperphagic ( 1 )

References 

1

Seong HA, Manoharan R, Ha H (2018) Smad proteins differentially regulate obesity-induced glucose and lipid abnormalities and inflammation via class-specific control of AMPK-related kinase MPK38/MELK activity. Cell Death Dis 9, 471
29700281   Curated Info

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