Ser49
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Home > Phosphorylation Site Page: > Ser49  -  RGS18 (human)

Site Information
KEKRNRLsLLVQKPE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451167

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 4 ) , immunoprecipitation ( 2 ) , mass spectrometry ( 1 , 4 ) , mutation of modification site ( 2 , 3 ) , phospho-antibody ( 2 , 3 ) , western blotting ( 2 , 3 )
Disease tissue studied:
luminal A breast cancer ( 1 ) , luminal B breast cancer ( 1 ) , breast cancer, triple negative ( 1 )
Relevant cell line - cell type - tissue:
breast ( 1 ) , HEK293T (epithelial) ( 2 , 3 ) , platelet-blood ( 2 )

Upstream Regulation
Treatments:
ADP ( 3 ) , colforsin ( 2 ) , thrombin ( 3 ) , TRAP ( 4 ) , TxA2 ( 3 )

Downstream Regulation
Effects of modification on RGS18:
molecular association, regulation ( 2 , 3 )
Effects of modification on biological processes:
signaling pathway regulation ( 3 )
Induce interaction with:
14-3-3 gamma (human) ( 2 , 3 )

References 

1

Mertins P, et al. (2016) Proteogenomics connects somatic mutations to signalling in breast cancer. Nature 534, 55-62
27251275   Curated Info

2

Gegenbauer K, Nagy Z, Smolenski A (2013) Cyclic nucleotide dependent dephosphorylation of regulator of g-protein signaling 18 in human platelets. PLoS One 8, e80251
24244663   Curated Info

3

Gegenbauer K, Elia G, Blanco-Fernandez A, Smolenski A (2012) Regulator of G-protein signaling 18 integrates activating and inhibitory signaling in platelets. Blood 119, 3799-807
22234696   Curated Info

4

García A, et al. (2004) Differential proteome analysis of TRAP-activated platelets: involvement of DOK-2 and phosphorylation of RGS proteins. Blood 103, 2088-95
14645010   Curated Info

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