Ser7
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Home > Phosphorylation Site Page: > Ser7  -  DAT (rat)

Site Information
_MsKsKCsVGPMssV   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 451136

In vivo Characterization
Methods used to characterize site in vivo:
2D analysis ( 2 ) , [32P] ATP in vitro ( 2 ) , [32P] bio-synthetic labeling ( 3 ) , mutation of modification site ( 1 , 2 , 3 ) , western blotting ( 2 , 3 )
Relevant cell line - cell type - tissue:
'brain, striatum' ( 2 ) , COS (fibroblast) ( 3 ) , LLC-PK1 (renal) ( 1 , 2 , 3 )

Upstream Regulation
Kinases, in vitro:
PKACA (human) ( 2 ) , PKCA (human) ( 2 )
Treatments:
okadaic_acid ( 2 ) , phorbol_ester ( 2 , 3 )

Downstream Regulation
Effects of modification on DAT:
intracellular localization ( 1 ) , molecular association, regulation ( 2 ) , protein conformation ( 2 )
Induce interaction with:
Other ( 2 )

References 

1

Moritz AE, et al. (2015) Reciprocal Phosphorylation and Palmitoylation Control Dopamine Transporter Kinetics. J Biol Chem 290, 29095-105
26424792   Curated Info

2

Moritz AE, et al. (2013) Phosphorylation of dopamine transporter serine 7 modulates cocaine analog binding. J Biol Chem 288, 20-32
23161550   Curated Info

3

Lin Z, et al. (2003) Phosphatidylinositol 3-kinase, protein kinase C, and MEK1/2 kinase regulation of dopamine transporters (DAT) require N-terminal DAT phosphoacceptor sites. J Biol Chem 278, 20162-70
12660249   Curated Info