Tyr275
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Home > Phosphorylation Site Page: > Tyr275  -  DVL2 (human)

Site Information
VTLNMEKyNFLGISI   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12170305

In vivo Characterization
Methods used to characterize site in vivo:
mass spectrometry ( 2 , 3 ) , mass spectrometry (in vitro) ( 1 ) , mutation of modification site ( 1 )
Disease tissue studied:
brain cancer ( 2 ) , astrocytoma ( 2 ) , testicular cancer ( 1 )
Relevant cell line - cell type - tissue:
F9 (testicular) ( 1 ) , Jurkat (T lymphocyte) ( 3 ) , U-118MG (glial) ( 2 )

Upstream Regulation
Kinases, in vitro:
Src (human) ( 1 )

Downstream Regulation
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Yokoyama N, Malbon CC (2009) Dishevelled-2 docks and activates Src in a Wnt-dependent manner. J Cell Sci 122, 4439-51
19920076   Curated Info

2

Tucker M (2009) CST Curation Set: 5978; Year: 2009; Biosample/Treatment: cell line, U118 MG/untreated; Disease: astrocytoma; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: pY Antibodies Used to Purify Peptides prior to LCMS: Phospho-Tyrosine Mouse mAb (P-Tyr-100) Cat#: 9411, PTMScan(R) Phospho-Tyr Motif (Y*) Immunoaffinity Beads Cat#: 1991
Curated Info

3

Mayya V, et al. (2009) Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. Sci Signal 2, ra46
19690332   Curated Info

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