Tyr201
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Home > Phosphorylation Site Page: > Tyr201  -  CTLA-4 (human)

Site Information
SPLTTGVyVKMPPTE   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 450897

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 2 ) , phospho-antibody ( 1 , 2 ) , western blotting ( 1 , 2 )
Relevant cell line - cell type - tissue:
Jurkat (T lymphocyte) ( 1 , 2 ) , T lymphocyte-blood ( 1 )

Upstream Regulation
Regulatory protein:
Lck (human) ( 2 ) , ZAP70 (human) ( 2 )
Treatments:
anti-CD3 ( 2 )

Downstream Regulation
Effects of modification on CTLA-4:
intracellular localization ( 2 ) , molecular association, regulation ( 1 )
Induce interaction with:
SHP-1 (human) ( 1 )

References 

1

Guntermann C, Alexander DR (2002) CTLA-4 suppresses proximal TCR signaling in resting human CD4(+) T cells by inhibiting ZAP-70 Tyr(319) phosphorylation: a potential role for tyrosine phosphatases. J Immunol 168, 4420-9
11970985   Curated Info

2

Baroja ML, et al. (2000) The inhibitory function of CTLA-4 does not require its tyrosine phosphorylation. J Immunol 164, 49-55
10604992   Curated Info