Thr197
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Home > Phosphorylation Site Page: > Thr197  -  Abl iso2 (human)

Site Information
VYHYRINtASDGKLy   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12121095

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , mutation of modification site ( 1 ) , phospho-antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
lung cancer ( 1 ) , non-small cell lung cancer ( 1 )
Relevant cell line - cell type - tissue:
293 (epithelial) ( 1 ) , MCF10A1 (epithelial) ( 1 ) , NCI-H1299 (pulmonary) ( 1 )

Upstream Regulation
Putative in vivo kinases:
LATS2 (human) ( 1 )
Kinases, in vitro:
LATS2 (human) ( 1 )

Downstream Regulation
Effects of modification on Abl iso2:
enzymatic activity, inhibited ( 1 )
Effects of modification on biological processes:
apoptosis, inhibited ( 1 )

References 

1

Reuven N, Adler J, Meltser V, Shaul Y (2013) The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl. Cell Death Differ 20, 1330-40
23852372   Curated Info

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