Thr358

Site Information
KKESRRAtESRIPVS SwissProt Entrez-Gene
Blast this site against: NCBI SwissProt PDB
Site Group ID: 12115364

In vivo Characterization
Methods used to characterize site in vivo:	[32P] ATP in vitro ( 1 ) , mass spectrometry ( 2 ) , mutation of modification site ( 1 )
Relevant cell line - cell type - tissue:	HEK293T (epithelial) ( 1 ) , Jurkat (T lymphocyte) ( 2 )

Upstream Regulation
Putative in vivo kinases:	Akt1 (human) ( 1 )
Kinases, in vitro:	Akt1 (human) ( 1 )
Treatments:	ETP47037 ( 1 ) , MK-2206 ( 1 )

Downstream Regulation
Effects of modification on TRF1:	molecular association, regulation ( 1 ) , phosphorylation ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:	carcinogenesis, induced ( 1 ) , cell growth, induced ( 1 ) , chromatin organization, altered ( 1 ) , transcription, inhibited ( 1 )
Induce interaction with:	DNA ( 1 )

References
1	Sánchez-Vázquez R, Martínez P, Blasco MA (2021) AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis. PLoS Genet 17, e1009410 33690611 Curated Info
2	Moritz A (2009) CST Curation Set: 8723; Year: 2009; Biosample/Treatment: cell line, Jurkat/calyculin_A; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS/T) Immunoaffinity Beads Cat#: 1978 Curated Info

References

Sánchez-Vázquez R, Martínez P, Blasco MA (2021) AKT-dependent signaling of extracellular cues through telomeres impact on tumorigenesis. PLoS Genet 17, e1009410
33690611 Curated Info

Moritz A (2009) CST Curation Set: 8723; Year: 2009; Biosample/Treatment: cell line, Jurkat/calyculin_A; Disease: T cell leukemia; SILAC: -; Specificities of Antibodies Used to Purify Peptides prior to LCMS: RXXp[ST] Antibodies Used to Purify Peptides prior to LCMS: Phospho-Akt Substrate (RXRXXS/T) (110B7) Rabbit mAb Cat#: 9614, PTMScan(R) Phospho-Akt Substrate Motif (RXXS*/T*) Immunoaffinity Beads Cat#: 1978
Curated Info