Lys290
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Home > Sumoylation Site Page: > Lys290  -  CREB (human)

Site Information
ARECRRKkKEYVkCL   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12063904

In vivo Characterization
Methods used to characterize site in vivo:
immunoprecipitation ( 1 ) , modification-specific antibody ( 1 ) , western blotting ( 1 )
Disease tissue studied:
colorectal cancer ( 1 ) , colorectal carcinoma ( 1 )
Relevant cell line - cell type - tissue:
BAE ( 1 ) , epithelial ( 1 ) , T84 (intestinal) ( 1 )

Upstream Regulation
Treatments:
hypoxia ( 1 )

Downstream Regulation
Effects of modification on CREB:
intracellular localization ( 1 ) , protein stabilization ( 1 )
Effects of modification on biological processes:
transcription, induced ( 1 )

References 

1

Comerford KM, et al. (2003) Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. Proc Natl Acad Sci U S A 100, 986-91
12552083   Curated Info