Ser16
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Home > Phosphorylation Site Page: > Ser16  -  Huntingtin (mouse)

Site Information
kAFEsLKsFQQQQQQ   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 12056100

In vivo Characterization
Methods used to characterize site in vivo:
immunoassay ( 4 ) , immunoprecipitation ( 2 , 4 ) , mutation of modification site ( 4 ) , phospho-antibody ( 2 , 3 , 4 ) , western blotting ( 2 , 3 , 4 )
Disease tissue studied:
Huntington's disease ( 2 )
Relevant cell line - cell type - tissue:
'brain, cerebral cortex' ( 4 ) , 'brain, striatum' ( 2 ) , 'neuron, cortical'-brain ( 3 ) , 'neuron, striatal'-brain ( 4 ) , 293 (epithelial) ( 4 )

Upstream Regulation
Treatments:
4b ( 3 ) , development ( 4 ) , fingolimod ( 2 )

Downstream Regulation
Effects of modification on Huntingtin:
intracellular localization ( 4 ) , molecular association, regulation ( 4 ) , protein degradation ( 4 )
Inhibit interaction with:
TPR (mouse) ( 4 )

References 

1

Cariulo C, et al. (2019) Ultrasensitive quantitative measurement of huntingtin phosphorylation at residue S13. Biochem Biophys Res Commun
31677786   Curated Info

2

Di Pardo A, et al. (2014) FTY720 (fingolimod) is a neuroprotective and disease-modifying agent in cellular and mouse models of Huntington disease. Hum Mol Genet 23, 2251-65
24301680   Curated Info

3

Jia H, Kast RJ, Steffan JS, Thomas EA (2012) Selective histone deacetylase (HDAC) inhibition imparts beneficial effects in Huntington's disease mice: implications for the ubiquitin-proteasomal and autophagy systems. Hum Mol Genet 21, 5280-93
22965876   Curated Info

4

Havel LS, et al. (2011) Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation. Hum Mol Genet 20, 1424-37
21245084   Curated Info