Tyr31
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Home > Phosphorylation Site Page: > Tyr31  -  PXN (rat)

Site Information
FLSEEPPySYPTGNH   SwissProt Entrez-Gene
Blast this site against: NCBI  SwissProt  PDB 
Site Group ID: 448785

In vivo Characterization
Methods used to characterize site in vivo:
mutation of modification site ( 4 , 5 ) , phospho-antibody ( 2 , 3 , 4 , 5 ) , western blotting ( 2 , 5 )
Disease tissue studied:
bladder cancer ( 5 )
Relevant cell line - cell type - tissue:
myocyte-heart ( 4 ) , NBT-II (bladder cell) ( 5 ) , REF52 (fibroblast) ( 2 ) , small mesenteric arteries ( 3 )

Upstream Regulation
Putative in vivo kinases:
FAK (human) ( 2 ) , Pyk2 (rat) ( 4 )
Treatments:
collagen_I ( 5 ) , cytochalasin_D ( 3 ) , endothelin ( 3 ) , norepinephrine ( 3 ) , PF-573228 ( 2 )

Downstream Regulation
Effects of modification on PXN:
activity, induced ( 5 ) , molecular association, regulation ( 5 )
Effects of modification on biological processes:
cell motility, altered ( 5 )
Induce interaction with:
CRK (rat) ( 5 ) , DOCK1 (human) ( 5 )

References 

1

Kwak TK, et al. (2010) Glucosamine Treatment-mediated O-GlcNAc Modification of Paxillin Depends on Adhesion State of Rat Insulinoma INS-1 Cells. J Biol Chem 285, 36021-31
20829364   Curated Info

2

Slack-Davis JK, et al. (2007) Cellular characterization of a novel focal adhesion kinase inhibitor. J Biol Chem 282, 14845-52
17395594   Curated Info

3

Ohanian V, Gatfield K, Ohanian J (2005) Role of the actin cytoskeleton in G-protein-coupled receptor activation of PYK2 and paxillin in vascular smooth muscle. Hypertension 46, 93-9
15911746   Curated Info

4

Melendez J, et al. (2004) Cardiomyocyte apoptosis triggered by RAFTK/pyk2 via Src kinase is antagonized by paxillin. J Biol Chem 279, 53516-23
15322113   Curated Info

5

Vallés AM, Beuvin M, Boyer B (2004) Activation of Rac1 by paxillin-Crk-DOCK180 signaling complex is antagonized by Rap1 in migrating NBT-II cells. J Biol Chem 279, 44490-6
15308668   Curated Info

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